CCD is an ongoing issue in some places; most research points to links with pesticides on crops. However, unless there are obvious signs of it in your area I'd be more worried (if that is the right word) with varroa and just keeping the hive clean and healthy.
I have found setting up with bees to be a tad costly. We got our hives second hand, but with hindsight I would strongly advise you to buy new, just to reduce the risk of disease - we spent hours sanding, disinfecting and scorching ours.
My costs so far:
Beekeeping course (highly recommended) £60
Suit £60
Tools (smoker, hive tool, bee brush) £40
Hives (My Dadants were £100 for 3 plus extras) usually start around £110
Frames and Foundation £80
Bees £120 per nuc
Sugar (in bulk!) £20
The list is probably much longer...I'd budget £500 to set yourself up with one hive and all of your kit. If you have a productive hive (ie a National producing 2 x 30lb supers per year, and selling 60lbs of honey at £4 per lb) you can expect to make your money back in a couple of years. Though financially, once they are set up the aren't costly to run - they run themselves as all you need to buy is sugar in winter and any treatments (varroa etc) that they may need.